Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaethylene in meconium specimens

D E Lewis1, C M Moore, J B Leikin

  • 1United States Drug Testing Laboratories, Chicago, Illinois.

Journal of Toxicology. Clinical Toxicology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inefficient transfer of diatoms through the subpolar Southern Ocean twilight zone.

Nature geoscience·2025
Same author

Advanced waveform analysis of diaphragm surface EMG allows for continuous non-invasive assessment of respiratory effort in critically ill patients at different PEEP levels.

Critical care (London, England)·2024
Same author

Analysis and applications of respiratory surface EMG: report of a round table meeting.

Critical care (London, England)·2024
Same author

Plant size, latitude, and phylogeny explain within-population variability in herbivory.

Science (New York, N.Y.)·2023
Same author

Transcriptional responses of Trichodesmium to natural inverse gradients of Fe and P availability.

The ISME journal·2021
Same author

ReIMAGINE: a prostate cancer research consortium with added value through its patient and public involvement and engagement.

Research involvement and engagement·2021
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
Same journal

Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil--a GABAA-gated chloride channel blocker.

Journal of toxicology. Clinical toxicology·2005
Same journal

Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats?

Journal of toxicology. Clinical toxicology·2005
Same journal

Position paper: gastric lavage.

Journal of toxicology. Clinical toxicology·2005
See all related articles

Cocaethylene, a cocaine and ethanol metabolite, was found in 31.6% of meconium specimens. This compound, cocaethylene, is a useful marker for identifying fetal alcohol exposure.

Area of Science:

  • Toxicology
  • Pharmacology
  • Neonatal research

Background:

  • Cocaethylene is a toxic metabolite formed from the combined use of cocaine and ethanol.
  • This compound is known to cause significant cardiac and neurobehavioral effects.

Purpose of the Study:

  • To determine the prevalence of cocaethylene in meconium specimens.
  • To evaluate cocaethylene as a biomarker for fetal exposure to alcohol and cocaine.

Main Methods:

  • Meconium samples initially positive for benzoylecgonine (via immunoassay) were analyzed.
  • Gas chromatography/mass spectrometry was used to quantify cocaine, cocaethylene, and benzoylecgonine.
  • Deuterated standards and a 5.0 ng/g cutoff were employed.

Main Results:

Related Experiment Videos

  • Out of 361 specimens positive for cocaine or benzoylecgonine, 114 (31.6%) tested positive for cocaethylene.
  • Cocaethylene concentrations were found to be higher in meconium compared to urine.
  • A significant correlation was observed between positive cocaethylene results and maternal substance use.

Conclusions:

  • Cocaethylene is prevalent in meconium, indicating fetal exposure.
  • Meconium analysis for cocaethylene can serve as a valuable tool for detecting combined cocaine and ethanol exposure in neonates.
  • This finding highlights the utility of meconium analysis in neonatal toxicology assessments.