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Ring or disc enhancing lesions in epilepsy in India
P P Sethi1, R S Wadia, D P Kiyawat
1Department of Neurology, Ruby Hall Clinic, Pune, India.
The Journal of Tropical Medicine and Hygiene
|December 1, 1994
Summary
Ring/disc enhancing lesions (RDELs) are common in Indian epilepsy patients, particularly children. Treatment with anticonvulsants alone resolves RDELs in most cases, with cysticercosis and tuberculosis as primary causes.
Area of Science:
- Neurology
- Radiology
- Infectious Diseases
Background:
- Ring/disc enhancing lesions (RDELs) are a frequent CT finding in epilepsy in India.
- These lesions present as hypodense areas on plain scans and show ring or disc-like enhancement post-contrast.
Purpose of the Study:
- To report on 186 cases of RDELs in focal epilepsy.
- To analyze the clinical characteristics, outcomes, and etiologies of RDELs in Indian epilepsy patients.
Main Methods:
- Retrospective analysis of 186 epilepsy cases with RDELs.
- Review of biopsy data from 16 cases and a meta-analysis of 58 biopsies from four Indian centers.
Main Results:
- RDELs were found in 26.1% of focal epilepsy cases, more common in children.
- Seventy-five percent of lesions resolved with anticonvulsant therapy alone.
- Cysticercosis and tuberculosis were the most common causes identified via biopsy.
Conclusions:
- RDELs are a significant finding in focal epilepsy in India, with a high resolution rate on anticonvulsants.
- Cysticercosis and tuberculosis are the leading etiologies, necessitating careful consideration in diagnosis and management.
- The high frequency of RDELs in India warrants further epidemiological and etiological investigation.