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Related Experiment Videos

[Quantitative evaluation of liver function with 99mTc-GSA scintigraphy using extraction index]

J Hashimoto1, A Ishibashi, T Kajitani

  • 1Department of Radiology, School of Medicine, Keio University.

Kaku Igaku. the Japanese Journal of Nuclear Medicine
|September 1, 1994
PubMed
Summary

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A new liver function test, the Extraction Index (EI5), shows strong correlation with liver function tests. This quantitative method using 99mTc-GSA scintigraphy offers a practical alternative to conventional indices.

Area of Science:

  • Nuclear Medicine
  • Hepatology
  • Medical Imaging

Background:

  • Quantitative liver function assessment is crucial for managing liver dysfunction.
  • Conventional indices like LHL15 and HH15 have limitations in accuracy and scope.
  • 99mTc-Galactosyl-Human Serum Albumin (GSA) scintigraphy is a valuable tool for liver imaging.

Purpose of the Study:

  • To introduce and evaluate the Extraction Index (EI5) as a novel quantitative measure of liver function.
  • To compare the efficacy of EI5 with conventional indices (LHL15, HH15) using 99mTc-GSA scintigraphy.
  • To assess the correlation of EI5 with established liver function tests.

Main Methods:

  • Performed 99mTc-GSA scintigraphy in 40 patients with liver dysfunction.
  • Calculated EI5 using a specific formula involving liver and heart region counts and pixel numbers.

Related Experiment Videos

  • Compared EI5 values with conventional indices (LHL15, HH15) and standard liver function tests.

    • Main Results:

    • EI5 demonstrated good correlations with liver function tests.
    • Correlation coefficients for EI5 were comparable to or higher than those for conventional parameters.
    • EI5 is a practical index, calculable quickly without computer assistance.
    • EI5's correction for pixel numbers may enable local liver function evaluation.

    Conclusions:

    • EI5 is a practical and effective quantitative index for assessing liver function via 99mTc-GSA scintigraphy.
    • EI5 shows superior or equivalent correlation with liver function tests compared to conventional indices.
    • The EI5 index holds potential for evaluating local liver function due to its pixel-correction feature.