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[Local therapy of Ewing sarcoma: radiotherapy aspects]
J Dunst1, S Jabar, M Paulussen
1Strahlentherapeutische Klinik und Poliklinik, Universität Erlangen-Nürnberg.
Klinische Padiatrie
|July 1, 1994
Summary
Radiotherapy and surgery offer similar survival rates for cancer treatment. Early radiotherapy in CESS 86 reduced local recurrences and systemic metastases compared to earlier trials.
Area of Science:
- Oncology
- Radiation Oncology
- Surgical Oncology
Background:
- Local treatment modalities in cancer therapy, including radiotherapy and surgery, are critical for patient survival.
- Previous studies (CESS 81) indicated a high local recurrence rate with definitive radiotherapy.
Purpose of the Study:
- To compare the efficacy of radiotherapy and surgery as local treatment modalities in CESS 86.
- To evaluate the impact of treatment timing and quality on radiotherapy outcomes.
Main Methods:
- Comparative analysis of survival rates, local recurrence, and systemic metastases between radiotherapy and surgery groups in CESS 86.
- Assessment of changes in local recurrence rates from CESS 81 to CESS 86, correlating with radiotherapy timing and protocol adherence.
Main Results:
- Similar survival rates were observed between radiotherapy and surgery groups in CESS 86.
- Radiotherapy patients had higher local recurrence (14% vs 4%) but lower systemic metastases (16% vs 28%) than surgical patients.
- Local recurrence rate significantly decreased from 50% in CESS 81 to 14% in CESS 86, attributed to earlier radiotherapy start and improved quality.
Conclusions:
- Early initiation and high-quality radiotherapy significantly improve local control.
- A combined approach of early irradiation followed by consolidative surgery for high-risk patients is a viable strategy.