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A new testicular feminization mutation found in C57BL/6J mice
S Tanaka1, T Kaneko, T Moriyama
1Laboratory Animal Research Center, University of Tokyo, Japan.
Laboratory Animals
|July 1, 1994
Summary
A novel testicular feminization (Tfm) mutation was identified in C57BL/6JJms mice, creating a new mutant strain. These Tfm mice exhibited intermediate body weights compared to normal males and females.
Area of Science:
- Genetics and Molecular Biology
- Developmental Biology
- Mammalian Genetics
Background:
- The testicular feminization (Tfm) mutation affects androgen receptor function.
- Previous studies have characterized various Tfm mouse strains.
- Understanding genetic mutations is crucial for developmental biology research.
Purpose of the Study:
- To establish and characterize a new mutant strain of mice with testicular feminization (Tfm).
- To compare the body weight of the novel Tfm mice with their normal littermates.
- To investigate potential differences in phenotypic expression compared to existing Tfm strains.
Main Methods:
- Isolation and breeding of a new Tfm mutant strain from C57BL/6JJms mice.
- Systematic recording of body weights for male, female, and Tfm mice.
- Comparative analysis of growth patterns across different age groups (5-40 weeks).
Main Results:
- A new Tfm mutant mouse line, C57BL/6JJms-TfmJms, was successfully established.
- Tfm mice displayed body weights intermediate between normal male and female mice.
- This growth pattern differs from previously reported Tfm mouse strains.
Conclusions:
- The newly developed C57BL/6JJms-TfmJms strain provides a valuable model for studying testicular feminization.
- Observed intermediate body weight suggests a unique phenotypic manifestation of Tfm in this strain.
- Further research comparing this strain with others can elucidate genotype-phenotype relationships in Tfm.