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Macrophages and renal disease
H Van Goor1, G Ding, D Kees-Folts
1Department of Pathology, University of Groningen, The Netherlands.
Abstract:
In this multimodel overview, we have provided the seminal experimental evidence for the crucial contribution of macrophages in the progression of glomerular and interstitial fibrosis. Although all the experimental data provided in this review definitely increase our understanding of the progress of renal disease, we have been mindful to use caution in extrapolating data from animal experiments to the clinical setting (109). In addition, uncertainty still exists as to whether macrophages activation entails a generalized mechanism in which the cells release growth factors and other mediators such as bioactive lipids and nitric oxide simultaneously, or a selective mechanism in which the cells release some but not all macrophage products (110). However, we anticipate that further substantial clinical and experimental observations are on the horizon. Novel therapeutic strategies in these models must be concerned with the prevention of renal macrophage recruitment and/or the suppression of the fibrogenic ability of this pluripotential inflammatory cell.
Insights
Macrophages play a key role in kidney fibrosis progression. This review highlights experimental evidence and discusses therapeutic strategies targeting macrophage recruitment and activation in renal disease.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Macrophages are implicated in the progression of kidney fibrosis.
- Understanding their role is crucial for managing renal diseases.
Purpose of the Study:
- To provide experimental evidence on the role of macrophages in renal fibrosis.
- To discuss potential therapeutic strategies targeting macrophages.
Main Methods:
- Multimodel overview of experimental evidence.
- Analysis of macrophage activation mechanisms.
Main Results:
- Macrophages are crucial in glomerular and interstitial fibrosis.
- Data from animal models require careful extrapolation to clinical settings.
- Uncertainty remains regarding generalized versus selective macrophage activation.
Conclusions:
- Macrophages are central to renal fibrosis.
- Future research should focus on clinical and experimental observations.
- Therapeutic strategies should target macrophage recruitment and fibrogenic potential.