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Related Experiment Videos

Postmortem distribution of zipeprol

Y Yoo1, H Chung, E Kim

  • 1National Institute of Scientific Investigation, Seoul, Korea.

Journal of Analytical Toxicology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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Zipeprol overdose fatalities have increased due to its abuse as a hallucinogen. Postmortem analysis revealed higher zipeprol concentrations in tissues than blood, with the stomach showing the highest levels.

Area of Science:

  • Forensic Toxicology
  • Pharmacology

Background:

  • Zipeprol, an antitussive, is abused for its hallucinogenic effects.
  • Increased fatalities from zipeprol overdose noted since 1991.

Purpose of the Study:

  • Determine postmortem distribution of zipeprol in tissues and blood.
  • Investigate zipeprol concentrations in decedents with a history of drug abuse.

Main Methods:

  • Analyzed blood and homogenized tissues from 23 decedents.
  • Used ethyl acetate extraction with cinnarizine as an internal standard.
  • Quantitated zipeprol using Gas Chromatography (GC) and identified using Gas Chromatography-Mass Spectrometry (GC-MS).

Main Results:

  • Blood zipeprol concentrations ranged from 2.3 to 38.3 µg/mL.

Related Experiment Videos

  • Highest zipeprol concentration detected in stomach tissue.
  • Postmortem tissue concentrations of zipeprol exceeded blood concentrations.

    • Conclusions:

    • Zipeprol distributes unevenly postmortem, accumulating significantly in tissues.
    • Stomach tissue is a key site for zipeprol accumulation after fatal overdose.
    • Findings aid in understanding zipeprol toxicology and overdose cases.