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Updated: Jul 27, 2026

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

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The association between PGE2 activity and mucosal permeability in proximal small bowel

J T Gerstle1, J Seaton, G L Kauffman

  • 1Division of General Surgery, Milton S. Hershey Medical Center, Penn State University, Hershey, Pennsylvania 17033.

The Journal of Surgical Research
|November 1, 1994
PubMed
Summary

Prostaglandin E2 production and cyclooxygenase activity increase with age in the developing rat gut, correlating with improved mucosal barrier function. Inhibiting prostaglandin synthesis in adult rats increased gut permeability.

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