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Effect of trichosanthin and momorcharins on isolated rat hepatocytes
1Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T.
Journal of Ethnopharmacology
|July 8, 1994
Abstract:
alpha-Momorcharin, beta-momorcharin and trichosanthin increased the secretion of glutamate-pyruvate transaminase, lactate dehydrogenase and isocitrate dehydrogenase by isolated rat hepatocytes into the culture medium. This hepatotoxic effect of the proteins appeared to be concentration-dependent. The plant proteins induced morphological changes in hepatocytes including increased formation of cytoplasmic blebs and a reduction of microvilli on plasma membrane.