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Angiotensin-converting enzyme inhibitor-induced pemphigus: three case reports and literature review
M K Kuechle1, K P Hutton, S A Muller
1Department of Dermatology, Mayo Clinic Rochester, MN 55905.
Objective:
To identify patients examined in the Mayo Clinic Department of Dermatology whose pemphigus was attributable to an angiotensin-converting enzyme inhibitor and to compare these cases with previously reported cases of drug-induced pemphigus.
Results:
A retrospective review of medical records revealed two cases of captopril-induced pemphigus and one of enalapril-induced pemphigus. Our patients had substantially increased circulating IgG autoantibodies to intercellular substance, as detected on monkey esophagus substrate.
Conclusion:
Our findings contrast those of other reports of drug-induced pemphigus in which circulating autoantibodies are implied to be low or absent.