Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain parenchyma apparent diffusion coefficient alterations associated with experimental complex partial status

A Righini1, C Pierpaoli, J R Alger

  • 1Neuroimaging Branch, NINDS, National Institutes of Health (NIH), Bethesda, MD 20892.

Magnetic Resonance Imaging
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline brain function in the preadolescents of the ABCD Study.

Nature neuroscience·2021
Same author

The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

AJNR. American journal of neuroradiology·2021
Same author

Ganglionic Eminence Anomalies and Coexisting Cerebral Developmental Anomalies on Fetal MR Imaging: Multicenter-Based Review of 60 Cases.

AJNR. American journal of neuroradiology·2021
Same author

Structural brain anomalies in Cri-du-Chat syndrome: MRI findings in 14 patients and possible genotype-phenotype correlations.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2020
Same author

Imitation strategies in subjects with schizophrenia: a behavioural approach.

Archives italiennes de biologie·2020
Same author

Imitation Strategies in Callosotomized Patients.

Archives italiennes de biologie·2018
Same journal

Repeatability of an MRI protocol for generating habitats based on cellularity, perfusion, and hypoxia in a murine model of glioma.

Magnetic resonance imaging·2026
Same journal

Association between CMR-derived pulmonary artery pulse wave velocity and pulmonary risk factors: the multi-ethnic study of atherosclerosis COPD study.

Magnetic resonance imaging·2026
Same journal

Systematic comparison of MPRAGE and BRAVO T1-weighted MRI pulse sequences and brain morphometry in high-risk young adults.

Magnetic resonance imaging·2026
Same journal

Foot dynamic contrast-enhanced MRI for assessing microcirculatory changes after endovascular therapy in peripheral artery disease: A prospective pilot study.

Magnetic resonance imaging·2026
Same journal

Reconstruction of MRI from undersampled k-spaces of double-contrast volume acquisitions using deep neural networks.

Magnetic resonance imaging·2026
Same journal

Radiofrequency-induced heating safety of brain MRI scans at 7 T in the presence of a shoulder implant.

Magnetic resonance imaging·2026
See all related articles

Apparent diffusion coefficient (ADC) MRI provides more specific information than T2-weighted MRI for tracking brain lesion evolution after seizures. This technique may aid in evaluating neuropathologic changes in patients with recurrent or prolonged seizures.

Area of Science:

  • Neuroimaging
  • Diffusion MRI
  • Epilepsy Research

Background:

  • Prolonged complex partial seizures can cause brain parenchyma lesions.
  • T2-weighted MRI and apparent diffusion coefficient (ADC) measurements are neuroimaging techniques.
  • Understanding lesion evolution is crucial for epilepsy management.

Purpose of the Study:

  • To compare the specificity of ADC measurements versus T2-weighted MRI in assessing brain lesion evolution.
  • To evaluate ADC changes in a rat model of kainic acid-induced seizures.
  • To determine the utility of diffusion MRI in studying seizure-induced neuropathology.

Main Methods:

  • Induced prolonged complex partial seizures in rats using kainic acid.
  • Utilized diffusion and T2-weighted MRI at 2 T for imaging.

Related Experiment Videos

  • Monitored brain regions including the piriform cortex and amygdala from 3 hours to 9 days post-injection.

    • Main Results:

    • T2-weighted MRI showed increased signal intensity in specific brain regions 24-72 hours post-seizure, normalizing by 9 days.
    • ADC measurements revealed a decrease followed by an increase in the same regions within 24-72 hours.
    • ADC changes correlated with known histopathologic alterations, indicating greater specificity.

    Conclusions:

    • ADC measurements offer more specific insights into seizure-induced lesion evolution than T2-weighted MRI.
    • Diffusion MRI shows promise for evaluating neuropathologic sequelae in patients experiencing multiple or prolonged seizures.
    • This study supports the use of diffusion MRI in clinical epilepsy research.