Related Experiment Videos
Prolonged penile erections induced by hydroxyzine: possible mechanism of action
J X Thavundayil1, R Hambalek, N M Kin
1Douglas Hospital Research Centre and Department of Chemistry, Verdun, Canada.
Neuropsychobiology
|January 1, 1994
Abstract:
We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.