Related Experiment Videos
Glucocorticoid treatment increases the ability of CRH to induce seizures
J B Rosen1, S K Pishevar, S R Weiss
1Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
Neuroscience Letters
|June 6, 1994
Abstract:
We examined whether glucocorticoids could enhance the ability of corticotropin-releasing hormone (CRH) to induce seizures. Rats were treated with systemic glucocorticoids (dexamethasone, 100 micrograms) or vehicle for either 3 days (chronic) or 2 h (acute) before intracerebroventricular CRH (3 or 10 micrograms) or saline injections and then monitored for 8 h following each injection. Our results suggest that chronic, but not acute, glucocorticoid pretreatment increases the likelihood of CRH-induced seizures.