[Malignant cystosarcoma phyllodes: clinico-pathological conference in connection with two cases]

Clinical and morphological characteristics of two malignant cystosarcoma phyllodes mammae were reported with the review of recent literature. One of the patients went to see her doctor 2 years after she had noticed the tumour because of "problems in her family". In the removed giant fibroadenoma osteo-chondrosarcomatous transformation was found. The other patient tried "to mobilise her inner energies against the growth" for 3 years. The removed tumour weighed 2100 grams and there were metastases in the axillary lymph nodes. Histological examination showed malignant cystosarcoma phyllodes with vasoformative tendency. Electron microscopical studies confirmed in both cases that the tumors with varying structures originated from immature mesenchymal cells. Authors agree on wide extirpation of the tumour. According to the literature adjuvant chemo- or radiotherapy do not improve patients survival. In case of early radical operation the malignant transformation is less probable.