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Related Experiment Videos

[Antianginal effect of transdermal isosorbide dinitrate (multicenter study)]

E Kékes1

  • 1Haynal Imre Egészségtudományi Egyetem, Budapest, II. sz. Belgyógyászati Klinika.

Orvosi Hetilap
|October 30, 1994
PubMed
Summary

Transdermal isosorbide dinitrate spray effectively reduced angina attacks and medication use in stable angina patients. The treatment showed a good safety profile with minimal side effects.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Stable angina pectoris is a common cardiovascular condition.
  • Effective management of angina symptoms is crucial for patient well-being.
  • Transdermal drug delivery offers potential advantages for chronic conditions.

Purpose of the Study:

  • To evaluate the efficacy and safety of transdermal isosorbide dinitrate spray.
  • To assess the impact on anginal attack frequency and medication consumption.
  • To determine patient tolerance and well-being during treatment.

Main Methods:

  • A study involving 167 patients with stable angina pectoris.
  • Administration of transdermal isosorbide dinitrate spray.
  • Monitoring of anginal attack frequency and sublingual medication use.
  • Assessment of side effects and patient well-being.

Main Results:

  • Transdermal isosorbide dinitrate spray significantly decreased the number of anginal attacks.
  • Reduced consumption of sublingual nitroglycerin and isosorbide dinitrate was observed.
  • The treatment was well-tolerated with very few reported side effects.

Conclusions:

  • Transdermal isosorbide dinitrate spray is an effective treatment for stable angina pectoris.
  • This delivery method improves symptom control and reduces rescue medication needs.
  • The favorable safety profile supports its use in managing angina.

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