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[The use of fluconazole in low-weight neonates with candidiasis]
N Saporito1, L G Tina, P Betta
1Istituto Clinica Pediatrica II, Università di Catania, Italia.
Abstract:
Systemic Candida Albicans infections in premature newborns are characterized by high morbidity; early diagnosis and immediate treatment are therefore necessary. In this study we report the cases of fourteen newborns admitted to our Newborn Care Unit in a three-year period, in whom candidiasis was diagnosed. The mycetes was isolated from blood, liquor, peritoneal fluid, urine, oesophageal aspirate. Treatment was undertaken immediately with fluconazole, administered through the parenteral route or locally into peritoneal cavum and oesophageal stump. Duration of treatment varied from five to twenty-one days. All cases underwent complete negativization of cultures and no systemic or local side effects.
Insights
Systemic Candida Albicans infections in premature newborns require prompt diagnosis and treatment. Fluconazole effectively treated candidiasis in fourteen newborns, with no adverse effects observed.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Mycology
Background:
- Systemic Candida Albicans infections pose significant morbidity risks in premature infants.
- Early detection and intervention are critical for improving outcomes in neonatal candidiasis.
Purpose of the Study:
- To report on the diagnosis and treatment of systemic candidiasis in fourteen premature newborns.
- To evaluate the efficacy and safety of fluconazole in treating neonatal candidiasis.
Main Methods:
- Retrospective case series of fourteen newborns diagnosed with candidiasis.
- Isolation of Candida Albicans from various bodily fluids and sites.
- Treatment with fluconazole administered parenterally or locally.
Main Results:
- Candida Albicans was isolated from blood, liquor, peritoneal fluid, urine, and oesophageal aspirates.
- All fourteen neonates received fluconazole treatment for 5 to 21 days.
- Complete negativization of cultures was achieved in all treated cases.
- No systemic or local side effects were reported during fluconazole treatment.
Conclusions:
- Fluconazole is an effective and safe treatment for systemic Candida Albicans infections in premature newborns.
- Prompt diagnosis and treatment with fluconazole can lead to favorable outcomes, including complete recovery.