[Hormonal-mediator interrelationships in polycystic ovary syndrome]

Examinations of 33 patients with the polycystic ovaries syndrome with measurements of monoamines, ovarian and gonadotropic hormones, and prolactin revealed disordered monoaminergic regulation in all the patients, manifesting by reduced dopamine level in normoprolactinemia and its reduction parallelled by increase of serotonin level in hyperprolactinemia. Disturbances in monoaminergic regulation result in increased level of LH and reduction of FSH levels in all the patients, as well as different prolactin levels. Hyperandrogenism in patients with the polycystic ovaries syndrome and normoprolactinemia is determined by a unidirectional increase of testosterone and androstenedione, whereas in hyperprolactinemia a sharp increase of testosterone content occurs in parallel with decrease of androstenedione level. Normal total estradiol level was associated in all the examinees with manifest relative hypoestrogenism. The detected disorders in hormonal-mediator relationships in patients with the polycystic ovaries syndrome give us new information on the pathogenesis of this condition, which may be important for its diagnosis and treatment.