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Echinococcus multilocularis: in vitro interactions between protoscolices and Kupffer cells

S Walbaum1, S al Nahhas, C Gabrion

  • 1INSERM Département de Parasitologie, Université Claude Bernard, Lyon, France.

Parasitology Research
|January 1, 1994
PubMed
Summary

Kupffer cells (Kc) interact with Echinococcus multilocularis protoscolices in liver cell cultures, potentially impacting parasite growth. These findings offer insights into host-parasite interactions in Echinococcosis.

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Area of Science:

  • Immunology
  • Parasitology
  • Cell Biology

Background:

  • Echinococcus multilocularis is a significant human and animal pathogen.
  • The interaction between parasite larvae and host immune cells is crucial for disease development.

Purpose of the Study:

  • To investigate the in vitro interaction between Echinococcus multilocularis protoscolices and rat Kupffer cells.
  • To elucidate the cellular mechanisms involved in this host-parasite interaction.

Main Methods:

  • Incubation of E. multilocularis protoscolices in rat hepatic cell cultures with or without feeder cells.
  • Scanning and transmission electron microscopy (SEM/TEM) for ultrastructural analysis.

Main Results:

  • Kupffer cells adhered to and phagocytosed protoscolices, targeting the tegument and microthrix.

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  • Parasite tegument showed alterations, including mitochondrial damage.
  • Feeder cells did not prevent Kupffer cell interaction with protoscolices.

    • Conclusions:

    • Kupffer cells exhibit immune activity against E. multilocularis protoscolices in vitro.
    • These interactions may influence the in vivo proliferation of metacestodes, suggesting a role for Kupffer cells in Echinococcosis pathogenesis.