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Percutaneous large-core breast biopsy: a multi-institutional study
S H Parker1, F Burbank, R J Jackman
1Breast Diagnostic and Counseling Centre, Radiology Imaging Associates, Englewood, CO 80111.
Radiology
|November 1, 1994
Summary
Automated large-core breast biopsy is a reliable alternative to surgical biopsy. This study confirms its reproducibility across multiple institutions for accurate breast cancer diagnosis.
Area of Science:
- Radiology and Oncologic Imaging
- Minimally Invasive Procedures
Background:
- Accurate breast lesion diagnosis is crucial for effective cancer treatment.
- Surgical biopsy has traditionally been the standard, but carries higher risks and costs.
Purpose of the Study:
- To evaluate the reliability and reproducibility of automated large-core breast biopsy.
- To compare its diagnostic accuracy against surgical biopsy outcomes.
Main Methods:
- A multi-institutional study involving 20 centers.
- Standardized collection of core breast biopsy data using 14-gauge needles and "long-throw" devices.
- Biopsies guided by stereotactic or ultrasound imaging.
Main Results:
- Data from 6,152 lesions were analyzed.
- In 1,363 surgically excised lesions, automated core biopsy showed cancer in 910, mammary intraepithelial neoplasia in 173, and benign disease in 280.
- A low false-negative rate of 15 out of 280 benign diagnoses was observed.
Conclusions:
- Percutaneous large-core breast biopsy demonstrates high reliability and reproducibility.
- It serves as a viable and accurate alternative to surgical biopsy for breast lesion evaluation.