Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nicotine place preference using the biased method of conditioning

D J Calcagnetti1, M D Schechter

  • 1Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|September 1, 1994
PubMed
Summary

Nicotine (NIC) induced a conditioned place preference (CPP) in rats when administered in their less-preferred environment. However, no significant change was observed when NIC was given in their preferred environment, suggesting a context-dependent effect.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continued trends in the conditioned place preference literature from 1992 to 1996, inclusive, with a cross-indexed bibliography.

Neuroscience and biobehavioral reviews·1998
Same author

'Candyflipping': synergistic discriminative effect of LSD and MDMA.

European journal of pharmacology·1998
Same author

Olanzapine attenuates the reinforcing effects of cocaine.

European journal of pharmacology·1998
Same author

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

Pharmacology, biochemistry, and behavior·1998
Same author

Rohypnol ("roofies") control of drug discrimination: effect of coadministered ethanol or flumenazil.

Pharmacology, biochemistry, and behavior·1998
Same author

LSD produces conditioned place preference in male but not female fawn hooded rats.

Pharmacology, biochemistry, and behavior·1998

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Nicotine is a psychoactive stimulant with known effects on the central nervous system.
  • Conditioned place preference (CPP) is a behavioral paradigm used to assess the rewarding properties of drugs.
  • Understanding nicotine's effects on behavior is crucial for addiction research.

Purpose of the Study:

  • To investigate if nicotine (NIC) administration induces a conditioned place preference (CPP) or aversion in rats.
  • To determine the influence of environmental context (preferred vs. less-preferred side) on NIC-induced CPP.
  • To explore potential common mechanisms underlying NIC-induced CPP and locomotor activity.

Main Methods:

  • Rats received subcutaneous injections of NIC (0.8 mg/kg) or saline.

Related Experiment Videos

  • Conditioning involved confining rats to either their preferred or less-preferred side of a three-compartment apparatus for 30 minutes over eight trials.
  • Locomotor activity was measured post-injection during a 30-minute test session.

    • Main Results:

    • Rats spent significantly more time in the compartment associated with NIC if it was initially less-preferred.
    • No significant change in compartment preference was observed when NIC was paired with the initially preferred side.
    • Nicotine administration at the tested dose also stimulated locomotor activity.

    Conclusions:

    • Nicotine (0.8 mg/kg) produces a conditioned place preference in rats, but only when paired with a less-preferred environment.
    • The rewarding effects of nicotine appear to be context-dependent.
    • The study suggests a potential common regulatory pathway involving mesolimbic dopamine neurons for both NIC-induced CPP and locomotor stimulation.