Iotrolan: a blood-isotonic nonionic dimer contrast agent for peripheral angiography

Area of Science:

• Radiology
• Medical Imaging
• Contrast Media

Background:

• Peripheral arteriography is crucial for diagnosing vascular diseases.
• Nonionic dimeric contrast media offer potential advantages in patient comfort and safety.
• Iotrolan 280 is a blood-isotonic, nonionic, dimeric contrast medium.

Purpose of the Study:

• To evaluate the safety and efficacy of iotrolan 280 in peripheral angiography.
• To assess patient-reported discomfort and objective safety parameters.

Main Methods:

• Phase III open trial involving 24 patients undergoing peripheral arteriography.
• Utilized objective and subjective tests to assess discomfort.
• Monitored blood chemistry, urinalysis, physical examinations, electrocardiograms, and blood pressure.

Main Results:

• Excellent opacification of peripheral arteries in all patients.
• Minimal patient-reported warm sensation and almost no pain during injection.
• No abnormalities in blood chemistry or urinalysis were observed.
• Physical examinations and monitoring confirmed the agent's safety.

Conclusions:

• Iotrolan 280 is a safe and effective contrast agent for peripheral angiography.
• The contrast medium is well-tolerated by patients, with minimal discomfort.
• No adverse effects were associated with its use in this study.