Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

99mTc-HMPAO planar white cell scanning

M J Weldon1

  • 1Dept. of Biochemical Medicine, St. George's Hospital and Medical School, London, UK.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A detailed lectin analysis of IgG glycosylation, demonstrating disease specific changes in terminal galactose and N-acetylglucosamine.

Journal of autoimmunity·1997
Same author

A seven-day Helicobacter pylori treatment regimen using clarithromycin, omeprazole and tripotassium dicitrato bismuthate.

Alimentary pharmacology & therapeutics·1996
Same author

Review article: quantitative leucocyte scanning in the assessment of inflammatory bowel disease activity and its response to therapy.

Alimentary pharmacology & therapeutics·1996
Same author

Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess.

Gut·1995
Same author

Quantification of inflammatory bowel disease activity using technetium-99m HMPAO labelled leucocyte single photon emission computerised tomography (SPECT).

Gut·1995
Same author

Lymphocyte and macrophage interleukin receptors in inflammatory bowel disease: a more selective target for therapy?

Gut·1994
Same journal

Abstract from the 41st Nordic Gastroenterology Congress, 8-11 June 2010, Copenhagen, Denmark.

Scandinavian journal of gastroenterology. Supplement·2010
Same journal

Abstracts from the XL Nordic Meeting of Gastroenterology, June 8-11, 2009, Stavanger, Norway.

Scandinavian journal of gastroenterology. Supplement·2009
Same journal

Abstracts of the 39th Nordic Meeting of Gastroenterology, 30th Nordic Meeting of Digestive Endoscopy, 18th Nordic Meeting of Gastrointestinal Motility, and the Annual Endoscopy/Gastroenterology Nurses'/Assistants' Meeting Post-graduate course, 4-6 June 2008, Helsinki, Finland.

Scandinavian journal of gastroenterology. Supplement·2008
Same journal

Abstracts from the XXXVIII Nordic Meeting of Gastroenterology, XXIX Nordic Meeting of Digestive Endoscopy, XVII Nordic Meeting of Gastrointestinal Motility, 6-9 June 2007, Reykjavik, Iceland.

Scandinavian journal of gastroenterology. Supplement·2007
Same journal

Abstracts of the XXXVII Nordic Meeting of Gastroenterology, 3-5 May 2006, Vasteras, Sweden.

Scandinavian journal of gastroenterology. Supplement·2006
Same journal

Novel approaches in the outpatient care of patients with chronic inflammatory bowel disease.

Scandinavian journal of gastroenterology. Supplement·2006
See all related articles

Technetium-99m-HMPAO white cell scanning is a reliable, non-invasive method for diagnosing inflammatory bowel disease (IBD). This imaging technique accurately assesses disease extent, severity, and complications like abscesses, aiding gastroenterologists in patient management.

Area of Science:

  • Medical Imaging
  • Gastroenterology
  • Nuclear Medicine

Background:

  • Effective management of inflammatory bowel disease (IBD) requires precise knowledge of inflammation's location, extent, and severity.
  • Early diagnostic approaches utilized Indium-111 labeled white cells.
  • Recent advancements introduced Technetium-99m-HMPAO white cell scanning.

Purpose of the Study:

  • To evaluate the efficacy of 99mTc-HMPAO white cell scanning in diagnosing and assessing inflammatory bowel disease.
  • To highlight the advantages of 99mTc-HMPAO white cell scanning over previous methods.

Main Methods:

  • Utilized 99mTc-HMPAO labeled white cells for imaging patients with suspected or known inflammatory bowel disease.
  • Assessed disease detection, extent, and severity through visual grading of uptake intensity.

Related Experiment Videos

  • Emphasized early (one-hour) imaging to avoid false positives and later imaging for localization.

    • Main Results:

    • 99mTc-HMPAO white cell scanning reliably detects IBD and assesses disease extent.
    • Improved image resolution enhances detection of small bowel disease, particularly ulcerating Crohn's disease.
    • The technique effectively identifies complicating abscesses and assesses the inflammatory component of strictures.

    Conclusions:

    • 99mTc-HMPAO white cell scanning is a sensitive and specific non-invasive test for IBD.
    • Early imaging at one hour is crucial for accurate assessment and avoiding false positives.
    • This highly informative test should be integrated into routine gastroenterological practice.