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Radiation-induced fibrosis: the structure/function relationship

J C Murray1

  • 1Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.

Scanning Microscopy
|March 1, 1994
PubMed
Summary
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Radiation therapy can cause fibrosis. This study in mice found that while collagen metabolism changes after X-ray irradiation, excessive connective tissue buildup does not explain late functional changes in the lung and colon.

Area of Science:

  • Radiation oncology
  • Medical physics
  • Biochemistry

Background:

  • Fibrosis is a common complication of therapeutic radiation.
  • Radiation-induced organ damage affects the thorax and pelvic region.

Purpose of the Study:

  • To investigate functional, biochemical, and structural changes in lung and colon after X-ray irradiation.
  • To determine if fibrosis is the cause of late functional changes.

Main Methods:

  • CBA mice were irradiated with 240 kV X-rays.
  • Lung function, collagen metabolism, and collagen isotype ratios were analyzed.
  • Colon compliance and protein synthesis were measured over time.

Main Results:

  • Irradiated lungs showed increased breathing rates and altered collagen metabolism, but no net collagen accumulation.

Related Experiment Videos

  • Irradiated colons exhibited decreased compliance with transient increases in collagen synthesis and breakdown.
  • The ratio of collagen types I to III increased in both organs post-irradiation.

    • Conclusions:

    • Late functional changes in irradiated mouse lungs and colons are not due to excessive connective tissue accumulation.
    • Changes in collagen metabolism occur early after irradiation but do not lead to fibrosis.
    • Radiation-induced fibrosis is not solely explained by collagen buildup.