[Functional and histological evidence of insulin resistance in spontaneously hypertensive rat]

In order to confirm the existence of insulin resistance in spontaneously hypertensive rat (SHR), rich musculature glucose tolerance test (GTT) and histological method examination of the insulin receptor were carried out in SHR and the normotensives (WKY). The basal serum insulin level was higher and the area under insulin curve during GTT was also higher in SHR than those in WKY, while the basal serum glucose level and the area under glucose curve during GTT in SHR were similar to those in WKY. As compared with WKY, SHR displayed a significantly lower percentage of insulin sensitive slow-twitch fiber of plantaris and medial head of gastrocnemius (type I fiber). There were strong positive correlations between blood pressure (BP) and insulin as well as between BP and the area under insulin curve, but the correlation between insulin and percentage of type I fiber was negative. In conclusion, the present study provides both functional and structural evidence of insulin resistance in SHR.