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Schistosomiasis and malignancy

L B Lemmer1, P J Fripp

  • 1Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|April 1, 1994
PubMed
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Schistosomiasis infection is linked to bladder cancer. This review explores the epidemiology, carcinogenic factors, and experimental evidence connecting chronic schistosomiasis infection to malignancy, including colon carcinoma.

Area of Science:

  • Urology
  • Oncology
  • Infectious Diseases

Background:

  • Schistosomiasis is widely recognized as a risk factor for malignancy, particularly bladder carcinoma.
  • Chronic bladder infection due to schistosomiasis is a significant concern in endemic areas.
  • The association between schistosomiasis and various cancers, including colon carcinoma, is an area of ongoing research.

Purpose of the Study:

  • To review the epidemiology of schistosomiasis and its association with bladder carcinoma.
  • To discuss the role of chronic schistosomiasis infection in the development of cancer.
  • To examine carcinogenic factors, vitamin metabolism, and conjugated carcinogens in the context of schistosomiasis-associated malignancies.

Main Methods:

  • Literature review of epidemiological studies on schistosomiasis and bladder carcinoma.

Related Experiment Videos

  • Examination of experimental evidence linking schistosomiasis to cancer.
  • Review of recent research on schistosomiasis and colon carcinoma, particularly from the Far East.

    • Main Results:

    • Epidemiological data supports a strong association between schistosomiasis and bladder carcinoma.
    • Chronic inflammation and specific carcinogenic pathways are implicated in schistosomiasis-related bladder cancer.
    • Experimental studies provide further evidence for the oncogenic potential of schistosomiasis.

    Conclusions:

    • Schistosomiasis is a significant risk factor for bladder cancer and potentially other malignancies.
    • Understanding the interplay of infection, carcinogens, and host factors is crucial for prevention and treatment.
    • Further research, especially on schistosomiasis and colon carcinoma, is warranted.