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Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro
D E Jackson1, C A Mitchell, H H Salem
1Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia.
Thrombosis and Haemostasis
|July 1, 1994
Abstract:
When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.