[The cytogenetic characteristics of subjects with menstrual function disorders]

The frequency and the pattern of chromosomal aberrations as well as the frequency of metaphase plates with premature chromatid disjunction, polyploidy and endoreduplication were studied in lymphocyte cultures of women with disturbances of the menstrual function and in healthy women. The frequency of metaphase plates was significantly increased in persons with Turner's syndrome and reduced in the groups with amenorrhea 1 and 2 in comparison with the group of healthy women. There was no difference in chromosomal aberration pattern. Premature chromatid disjunction is characteristic of patients with disturbances of the menstrual function and healthy women. The frequency of metaphase plates with premature chromatid disjunction was elevated in groups with Turner's syndrome, amenorrhea 1 and premature sexual maturation in comparison with the control.