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Stroke. Revolution in therapy

D R Gress1

  • 1Department of Neurology, University of California, San Francisco, School of Medicine 94143-0114.

The Western Journal of Medicine
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Stroke is a leading cause of death, but new research offers hope. Advances in stroke prevention and acute interventions, including glutamate antagonists and reperfusion therapies, are transforming emergency stroke care.

Area of Science:

  • Neurology
  • Emergency Medicine
  • Pharmacology

Background:

  • Stroke is a leading cause of death, necessitating advancements in treatment.
  • Recent research has revolutionized the understanding and management of stroke.
  • Primary and secondary stroke prevention strategies can avert thousands of cases annually.

Purpose of the Study:

  • To review evolving strategies for acute stroke intervention.
  • To highlight the role of ischemia and calcium accumulation in stroke pathology.
  • To discuss promising therapeutic targets and ongoing clinical trials for stroke treatment.

Main Methods:

  • Review of experimental stroke models and clinical trial data.
  • Examination of the pathophysiology of ischemic stroke, including excitotoxicity and free radical formation.

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  • Analysis of therapeutic approaches such as glutamate antagonists, revascularization, and free radical scavengers.

    • Main Results:

    • Glutamate antagonists show promise in experimental models, with clinical trials initiated.
    • Acute revascularization techniques are feasible for restoring perfusion and minimizing infarction.
    • Fibrinolytic agents demonstrate potential, and clinical studies are underway.
    • Free radical scavenging agents are being tested to mitigate reperfusion injury.

    Conclusions:

    • Understanding ischemia and excitotoxicity is crucial for developing new stroke therapies.
    • Emerging pharmacologic agents and interventions are making stroke a treatable neurologic emergency.
    • Immediate intervention is critical for improving outcomes in acute stroke cases.