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[SAPHO syndrome]

A M Chamot1, M F Kahn

  • 1Service de Rhumatologie, Médecine physique et Réhabilitation, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.

Zeitschrift Fur Rheumatologie
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis, links severe skin conditions with musculoskeletal issues. This review details its clinical, diagnostic, and management aspects.

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Area of Science:

  • Dermatology and Rheumatology
  • Immunogenetics
  • Pathophysiology

Context:

  • Musculoskeletal manifestations like synovitis, arthroosteitis, and osteomyelitis are associated with severe acne, palmoplantar pustulosis, and psoriasis.
  • Previous literature describes these conditions under various terms, highlighting a need for unified classification.
  • Recent findings suggest a link to spondarthritides, indicated by increased HLA B27 prevalence and associated conditions like sacroiliitis and inflammatory bowel disease.

Purpose:

  • To propose and define the SAPHO syndrome (Synovitis, Acne, Pustulosis Hyperostosis, and Osteitis) as a unifying term for these related conditions.
  • To review the clinical, epidemiological, pathophysiological, and immunogenetic aspects of SAPHO syndrome.
  • To provide an overview of diagnostic strategies and management options for patients with SAPHO syndrome.

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Summary:

  • SAPHO syndrome encompasses a spectrum of diseases linking severe dermatological conditions (acne, pustulosis, psoriasis) with characteristic musculoskeletal inflammatory findings.
  • Key features include synovitis, chest wall arthroosteitis, and multifocal osteomyelitis, with potential associations to spondarthropathies and specific genetic markers like HLA B27.
  • The review consolidates current knowledge on the syndrome's multifaceted presentations and proposes a standardized approach to its understanding and treatment.

Impact:

  • Establishes a clear definition and acronym (SAPHO syndrome) for a group of previously variably described conditions.
  • Facilitates better recognition and diagnosis of SAPHO syndrome, improving patient management and outcomes.
  • Provides a comprehensive resource for clinicians and researchers, advancing the understanding of the interplay between skin and bone inflammatory diseases.