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Does the loop electrosurgical excision procedure adversely affect the histopathological interpretation of cervical
1Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei.
Acta Obstetricia Et Gynecologica Scandinavica
|October 1, 1994
Summary
Loop electrosurgical excision procedure (LEEP) provides well-preserved cervical tissue samples suitable for histopathological interpretation. Thermal damage from LEEP is limited and does not impede diagnosis.
Area of Science:
- Gynecologic Pathology
- Cervical Cancer Screening
- Surgical Pathology
Background:
- Loop electrosurgical excision procedure (LEEP) is a common method for treating cervical intraepithelial neoplasia.
- Assessing the histopathological quality of LEEP specimens is crucial for accurate diagnosis and patient management.
Purpose of the Study:
- To evaluate the suitability of conized specimens obtained via LEEP for histopathological interpretation.
- To quantify thermal damage associated with LEEP and assess its impact on tissue quality.
Main Methods:
- Histological examination of 215 LEEP tissue sections from 32 patients with cervical intraepithelial neoplasia.
- Quantification of thermal damage (carbonization and coagulation zones) using microscopy and a calibrated grid.
- Assessment of tissue distortion in relation to thermal damage.
Main Results:
- Thermal damage, comprising carbonization and coagulation zones, ranged from 160 to 520 mu.
- The coagulation zone was significantly deeper than the carbonization zone (p < 0.0001).
- Tissue distortion was observed in 53% of cases, confined to the coagulation zone.
Conclusions:
- LEEP specimens generally exhibit well-preserved tissue structure.
- The extent of thermal damage is limited and does not typically pose diagnostic challenges.
- LEEP is a reliable technique for obtaining adequate tissue samples for histopathological examination.