Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exocrine-gland function and the basic biochemical defect in cystic fibrosis

L G Dann, K Blau

    Lancet (London, England)
    |August 19, 1978
    PubMed
    Summary

    A proposed biochemical factor, kinin E, links secretion and reabsorption in exocrine glands. In cystic fibrosis, defective arginine esterases may prevent kinin E formation, causing abnormal ion reabsorption and disease symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Killing of Brucella abortus by bovine serum.

    Infection and immunity·1988
    Same author

    Serum susceptibility of Haemophilus somnus from bovine clinical cases and carriers.

    Journal of clinical microbiology·1985
    Same author

    Activities of alkaline phosphatase in first trimester chorion biopsy tissue.

    Prenatal diagnosis·1985
    Same author

    Severe pre-eclampsia of early onset.

    British medical journal (Clinical research ed.)·1983
    Same author

    Hyperphenylalaninemia with defective transamination.

    Clinica chimica acta; international journal of clinical chemistry·1983
    Same author

    Determination of phenylalanine in filter paper blood spots by a simplified automated fluorimetric method without dialysis.

    Clinica chimica acta; international journal of clinical chemistry·1983

    Area of Science:

    • Biochemistry
    • Physiology
    • Molecular Biology

    Background:

    • Exocrine glands play a crucial role in secretion and reabsorption.
    • Cystic fibrosis is a genetic disorder affecting exocrine glands.
    • Understanding the molecular mechanisms of ion transport in exocrine glands is vital.

    Purpose of the Study:

    • To propose a biochemical link between secretion and reabsorption in exocrine glands.
    • To investigate the role of a specific factor, kinin E, in ion reabsorption.
    • To explore the potential defects in cystic fibrosis.

    Main Methods:

    • Biochemical analysis of exocrine gland function.
    • Investigation of arginine esterase activity.
    • Study of kinin E formation and function.

    Main Results:

    • A novel factor, kinin E, is proposed to initiate ion reabsorption.
    • Kinin E activation involves arginine esterases.
    • Defective arginine esterases in cystic fibrosis may impair kinin E formation.

    Conclusions:

    • A biochemical link involving kinin E connects secretion and reabsorption.
    • Defective kinin E formation due to impaired arginine esterases is implicated in cystic fibrosis.
    • Abnormal ion reabsorption in cystic fibrosis leads to disease manifestations.

    Related Experiment Videos