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Pituitary-adrenocortical responsiveness to histaminergic stimulation during social stress of crowding in rats
A Gadek-Michalska1, J Borycz, J Bugajski
1Institute of Pharmacology, Polish Academy of Sciences, Kraków.
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|June 1, 1994
Abstract:
Social stress of crowding for 3, 7, 14 and 21 days drastically reduces the serum corticosterone response to intracerebroventricular administration of dimaprit, a histamine H2-receptor agonist, moderately diminishes the response to pyridylethylamine, an H1-receptor agonist, and does not change significantly the corticosterone response to histamine. These results suggest that social stress of crowding considerably desensitizes central histamine H2-receptors involved in stimulation of the hypothalamic-pituitary-adrenal axis.