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Circulating immune complexes in rabbits surviving rinderpest virus infection
B Rattan1, B Sharma, R P Bansal
1Division of Virology, Indian Veterinary Research Institute, District Nainital, U.P.
Acta Virologica
|April 1, 1994
Summary
Circulating immune complexes containing rinderpest virus (RPV) antigen were detected in recovered rabbits, persisting for over 77 days. These non-infectious complexes provide insights into RPV infection dynamics.
Area of Science:
- Veterinary Virology
- Immunology
Background:
- Rinderpest virus (RPV) causes a severe, contagious disease in ruminants.
- Understanding the host immune response to RPV is crucial for disease control.
Purpose of the Study:
- To characterize circulating immune complexes (CICs) in rabbits infected with a virulent RPV strain.
- To investigate the antigenic properties and persistence of these CICs.
Main Methods:
- Precipitation of CICs from rabbit sera post-RPV infection.
- Chromatographic isolation of RPV antigen from CICs.
- ELISA and antibody detection assays were employed.
Main Results:
- CICs containing RPV antigen and rabbit IgG were identified and persisted for at least 77 days.
- Isolated CICs and antigen were non-infectious.
- Antigenic components of CICs competed with both attenuated and virulent RPV strains in ELISA.
- Similar CICs were absent in vaccinated calves.
Conclusions:
- RPV infection induces persistent CICs in rabbits, containing non-infectious viral antigen.
- These CICs possess antigenic properties that can be used for diagnostic or immunological studies.
- The absence of CICs in vaccinated calves suggests differences in immune response compared to natural infection.