Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endocrine changes associated with a rapidly developing sodium appetite in rats

R L Thunhorst1, M Morris, A K Johnson

  • 1Department of Psychology, University of Iowa, Iowa City 52242-1407.

The American Journal of Physiology
|November 1, 1994
PubMed
Summary

Combining furosemide and low-dose captopril triggers thirst and sodium appetite in rats. This response is linked to brain-formed angiotensin II, not circulating levels, highlighting central mechanisms in fluid regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing a novel laser enrichment device for broilers: Evaluating an 8-minute exposure four times daily on broiler performance, walking distance behavior, and leg health.

Poultry science·2026
Same author

"I am so grateful you made me do this": Navigating AYA-Caregiver Discordance on Shared Decision-making about Fertility Preservation.

Journal of pediatric and adolescent gynecology·2025
Same author

Observations about declining fertility in a feline breeding colony.

Theriogenology·2023
Same author

Changes in HIV Prevention and Sexual Experiences During the COVID-19 Pandemic: A Mixed-Methods Study.

Journal of acquired immune deficiency syndromes (1999)·2023
Same author

Increased duration of laser environmental enrichment increased broiler physical activity and pen-wide movement without altering tibia measurements.

Poultry science·2023
Same author

Breast muscle white striping and serum corticosterone reduced in broilers exposed to laser environmental enrichment.

Poultry science·2023

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Fluid intake and balance are regulated by complex hormonal systems.
  • Angiotensin II plays a crucial role in mediating thirst and sodium appetite.
  • Diuretics like furosemide and ACE inhibitors like captopril impact fluid and electrolyte balance.

Purpose of the Study:

  • To investigate the hormonal mechanisms underlying thirst and sodium appetite induced by combined furosemide and low-dose captopril administration in rats.
  • To determine the role of circulating versus centrally generated angiotensin II in mediating these behaviors.

Main Methods:

  • Rats were administered furosemide and varying doses of captopril.
  • Plasma levels of renin activity, angiotensin I, aldosterone, vasopressin, and oxytocin were measured.

Related Experiment Videos

  • Behavioral responses, including water and NaCl intake, were monitored.

    • Main Results:

    • Combined furosemide and low-dose captopril significantly increased plasma renin activity, angiotensin I, and vasopressin.
    • Aldosterone levels were comparable to those seen with individual drug administration.
    • A higher dose of captopril with furosemide abolished the vasopressin increase, despite elevated renin and angiotensin I.
    • Thirst and sodium appetite were observed with the low-dose captopril combination.

    Conclusions:

    • The findings support the hypothesis that thirst and salt appetite induced by furosemide and low-dose captopril are mediated by centrally generated angiotensin II within brain circumventricular organs.
    • Systemic angiotensin II levels may not be the primary driver of this specific behavioral response.
    • This study elucidates the central neuroendocrine pathways involved in regulating fluid intake and appetite.