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Related Experiment Videos

Altered antroduodenal motility after cholecystectomy

G Perdikis1, P Wilson, R Hinder

  • 1Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska.

American Journal of Surgery
|December 1, 1994
PubMed
Summary

Post-cholecystectomy patients exhibit altered antroduodenal motility and increased duodenogastric reflux (DGR). These motility changes and DGR are more pronounced in patients experiencing persistent symptoms after gallbladder removal.

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Area of Science:

  • Gastroenterology
  • Digestive Physiology

Background:

  • Nonspecific symptoms like epigastric pain and nausea are common after cholecystectomy.
  • The exact cause of these post-cholecystectomy symptoms is unclear, but abnormal antroduodenal motility and duodenogastric reflux (DGR) are suspected.
  • This study investigates the relationship between motility, DGR, and symptoms in post-cholecystectomy patients.

Purpose of the Study:

  • To evaluate antroduodenal motility and duodenogastric reflux (DGR) in patients following cholecystectomy.
  • To determine if motility abnormalities and DGR correlate with the presence and severity of post-cholecystectomy symptoms.

Main Methods:

  • Studied 16 post-cholecystectomy patients (10 asymptomatic, 6 symptomatic) and 19 healthy volunteers.
  • Utilized 99mTc-DISIDA infusion for DGR assessment, 24-hour intragastric pH monitoring, and 24-hour ambulatory antroduodenal manometry.

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Main Results:

  • Post-cholecystectomy patients showed significantly increased DGR, particularly symptomatic patients.
  • Elevated intragastric pH (>3) was observed more frequently in symptomatic patients.
  • Antral phase III frequency was reduced, and duodenal phase III propagation and duration were significantly impaired in post-cholecystectomy patients compared to controls.

Conclusions:

  • Fasting antroduodenal motility is demonstrably altered after cholecystectomy.
  • These motility alterations are linked to increased duodenogastric reflux (DGR).
  • The severity of DGR is greater in symptomatic post-cholecystectomy patients, suggesting a role in symptom development.