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Related Experiment Videos

Left stellate ganglion block impairs left ventricular function

W Schlack1, S Schäfer, V Thämer

  • 1Abteilung für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität, Düsseldorf, Germany.

Anesthesia and Analgesia
|December 1, 1994
PubMed
Summary

Left stellate ganglion block (LSGB) impairs cardiac contractility and increases LV asynchrony. This study investigated the effects of LSGB on regional myocardial function in dogs.

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Area of Science:

  • Cardiology
  • Autonomic Nervous System
  • Cardiac Electrophysiology

Background:

  • Stellate ganglion block (SGB) is used for chronic pain management.
  • SGB can cause sympathetic denervation, potentially affecting left ventricular (LV) function.
  • Imbalances in myocardial contractility may lead to adverse LV function and asynchrony.

Purpose of the Study:

  • To investigate the impact of left stellate ganglion block (LSGB) on regional LV contractility and asynchrony.
  • To assess changes in myocardial contractility and wall motion timing after LSGB.
  • To evaluate LV diastolic function following LSGB.

Main Methods:

  • Seven anesthetized open-chest dogs were instrumented for hemodynamic and regional LV function measurements.
  • Measurements included aortic/LV pressure, cardiac output, and regional LV wall thickness (sonomicrometry).

Related Experiment Videos

  • Contractility (MW), wall motion timing, LV asynchrony (PD), and diastolic function (tau) were assessed before and after LSGB.

    • Main Results:

    • LSGB significantly reduced posterobasal myocardial contractility (MW).
    • A delay in regional wall motion timing was observed post-LSGB.
    • Cardiac output and mean arterial pressure remained unchanged, but LV asynchrony increased.

    Conclusions:

    • LSGB acutely impairs regional myocardial contractility and wall motion in the posterobasal LV.
    • LSGB can induce or worsen LV asynchrony due to regional contractility imbalances.
    • These findings highlight potential cardiac implications of SGB procedures.