Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vancomycin anaphylaxis and successful desensitization

S Anne'1, E Middleton, R E Reisman

  • 1Buffalo General Hospital, NY 14203.

Annals of Allergy
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact and utilisation of patient-initiated follow-ups (PIFU) in the elective upper-limb clinic at secondary care.

Annals of the Royal College of Surgeons of England·2025
Same author

Complexation reduces nickel toxicity to purple sea urchin embryos (Strongylocentrotus purpuratus), a test of biotic ligand principles in seawater.

Ecotoxicology and environmental safety·2021
Same author

PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Cost effectiveness of the Expert Patients Programme (EPP) for patients with chronic conditions.

Journal of epidemiology and community health·2008
Same author

Reductions in cardiovascular risk in association with population screening: a 10-year longitudinal study.

Journal of public health (Oxford, England)·2007
Same author

Cervical screening and health inequality in England in the 1990s.

Journal of epidemiology and community health·2003

Vancomycin anaphylaxis can be successfully treated with a prolonged desensitization protocol. This method allows allergic patients to receive vancomycin when no other treatment options exist.

Area of Science:

  • Clinical Medicine
  • Immunology
  • Pharmacology

Background:

  • Vancomycin is a critical antibiotic for treating serious Gram-positive bacterial infections.
  • Anaphylaxis to vancomycin, though rare, presents a significant challenge in patient management.
  • Alternative antibiotics may have limitations or be less effective, necessitating vancomycin use.

Observation:

  • A 35-year-old woman experienced anaphylaxis, including urticaria and respiratory distress, upon vancomycin re-administration.
  • Standard desensitization protocols and supportive medications failed to prevent recurrent allergic reactions.
  • Intradermal skin testing revealed hypersensitivity to vancomycin at very low concentrations.

Findings:

  • A 13-day sequential intravenous vancomycin dose escalation protocol successfully desensitized the patient.

Related Experiment Videos

  • Following desensitization, the patient tolerated the full therapeutic dose of vancomycin.
  • Skin test reactivity to vancomycin diminished after successful desensitization.

    • Implications:

    • Prolonged vancomycin desensitization is a viable strategy for managing patients with confirmed anaphylaxis.
    • This approach offers a crucial treatment option when alternative antibiotics are unsuitable.
    • Further research into optimizing desensitization protocols for vancomycin hypersensitivity is warranted.