Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sinonasal lymphomas

K R Cleary1, J G Batsakis

  • 1Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston.

The Annals of Otology, Rhinology, and Laryngology
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular and biomarker analyses of salivary duct carcinomas: comparison with mammary duct carcinoma.

International journal of oncology·2001
Same author

Schneiderian papillomas and carcinomas: a review.

Advances in anatomic pathology·2001
Same author

Sarcomatoid carcinomas of the upper aerodigestive tracts.

Advances in anatomic pathology·2000
Same author

Papillary squamous cell carcinomas of the upper aerodigestive tract: a clinicopathologic and molecular study.

Head & neck·2000
Same author

Mucosal melanomas: a review.

Advances in anatomic pathology·2000
Same author

Proliferative verrucous leukoplakia and its related lesions.

Oral oncology·2000
Same journal

Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

The Annals of otology, rhinology, and laryngology·2026
See all related articles

Midfacial necrotizing lesions are now understood to be primarily sinonasal lymphomas, not distinct diseases. Advances in diagnostics clarify their B- or T-cell lineage and biologic spectrum, aiding management.

Area of Science:

  • Immunopathology
  • Molecular Genetics
  • Oncology

Background:

  • Traditional nomenclature for midfacial necrotizing lesions lacked diagnostic clarity and therapeutic guidance.
  • Previous terms like midline granuloma syndrome and polymorphic reticulosis are now obsolete.
  • These lesions were historically difficult to classify and manage effectively.

Purpose of the Study:

  • To clarify the histopathologic and therapeutic landscape of midfacial necrotizing lesions.
  • To update the diagnostic nomenclature based on recent scientific advancements.
  • To differentiate these lesions from other conditions and guide treatment strategies.

Main Methods:

  • Immunocytochemical phenotyping to determine cell lineage (B-cell or T-cell).
  • Molecular genetics to analyze the biologic spectrum and grade of lymphomas.

Related Experiment Videos

  • Review and reclassification of previously diagnosed cases.

    • Main Results:

    • The majority of midfacial necrotizing lesions are sinonasal lymphomas, not distinct entities.
    • These lymphomas exhibit a broad biologic spectrum, ranging from low to high grade.
    • Lesions are confirmed to be of either B-cell or T-cell lineage.

    Conclusions:

    • Modern diagnostic techniques have resolved previous ambiguities in classifying midfacial necrotizing lesions.
    • Sinonasal lymphomas represent the primary diagnosis for these conditions.
    • Further research is needed on geographic variations and optimal therapeutic regimens for T-cell lymphomas.