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[Rheological parameters in hemorrhoid pathology]

J Denis1, J M Garrigues, J P Trochet

  • 1Hôpital Léopold Bellan, Paris.

Annales De Gastroenterologie Et D'Hepatologie
|September 1, 1994
PubMed
Summary

Erythrocyte aggregation, a marker of circulatory stasis, was significantly higher in hemorrhoidal disease patients compared to healthy individuals. Acute hemorrhoid cases showed the most pronounced increases, linked to elevated fibrinogen levels.

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Area of Science:

  • Vascular Biology
  • Hematology
  • Gastroenterology

Background:

  • Hemorrhoidal disease is a common condition.
  • Circulatory stasis is implicated in the pathophysiology of hemorrhoids.
  • Hemorheological parameters may serve as indicators of disease severity.

Purpose of the Study:

  • To investigate erythrocyte aggregation in patients with hemorrhoidal disease.
  • To compare erythrocyte aggregation between different stages of hemorrhoidal disease and healthy controls.
  • To explore the relationship between erythrocyte aggregation, fibrinogen levels, and hemorrhoidal disease.

Main Methods:

  • Erythrocyte aggregation index was measured in 62 patients with hemorrhoidal disease and 21 healthy controls.
  • Patients were categorized into three groups based on proctoscopy: recent uncomplicated congestive attack, recent thrombosed hemorrhoid, and stage IIb or III chronic prolapse.

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  • Blood fibrinogen levels were also assessed in patients.

    • Main Results:

    • Erythrocyte aggregation index was significantly higher in patients with hemorrhoidal disease (31.6 +/- 6.8) compared to healthy controls (27.7 +/- 4.4) (p < 0.05).
    • The most significant increase in erythrocyte aggregation was observed in patients experiencing acute hemorrhoid problems.
    • A parallel increase in blood fibrinogen was noted in patients with acute hemorrhoidal conditions.

    Conclusions:

    • Elevated erythrocyte aggregation is a characteristic hemorheological alteration in hemorrhoidal disease.
    • Acute hemorrhoidal episodes are associated with heightened erythrocyte aggregation and increased fibrinogen.
    • These hemorheological changes may exacerbate venous stasis and contribute to thrombosis in the hemorrhoidal circulation.