Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The two locus problem

J H Edwards1

  • 1Genetics Laboratory, Biochemistry Department, Oxford, UK.

Annals of Human Genetics
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

This study introduces a method to detect genetic linkage between similar phenotypes and marker loci within families. The term "amphigenic" is proposed for these specific genetic conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haldane and the analysis of linkage.

Journal of genetics·2017
Same author

THE SIGNIFICANCE OF PHLEBOLITHS.

British medical journal·2010
Same author

Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

European cells & materials·2010
Same author

Aetiology and outcomes of adult superior oblique palsies: a modern series.

Eye (London, England)·2008
Same author

Amendment effects on soil test phosphorus.

Journal of environmental quality·2005
Same author

Sib-pairs in multifactorial disorders: the sib-similarity problem.

Clinical genetics·2003
Same journal

FIGLA Novel Variant c.385-9G>A Affects RNA Splicing in a Minigene Assay.

Annals of human genetics·2026
Same journal

Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.

Annals of human genetics·2026
Same journal

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

Annals of human genetics·2026
Same journal

A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency.

Annals of human genetics·2026
Same journal

Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis.

Annals of human genetics·2026
Same journal

Genetic Insights Into Hypertension and Breast Cancer Risk in African Women: A Mendelian Randomization and Colocalization Analyses.

Annals of human genetics·2026
See all related articles

Area of Science:

  • Genetics
  • Statistical genetics
  • Human genetics

Background:

  • Detecting genetic linkage is crucial for understanding disease inheritance.
  • Similar phenotypes can complicate the identification of linked genetic loci.
  • Family-based studies are essential for genetic linkage analysis.

Purpose of the Study:

  • To address the challenge of detecting linkage between phenotypes and marker loci in family studies.
  • To propose a novel term for conditions exhibiting linkage between similar phenotypes and multiple marker loci.

Main Methods:

  • Discusses the problem of identifying genetic linkage using family data.
  • Develops a solution for detecting linkage between phenotypic traits and genetic markers.
  • Employs statistical methods for analyzing familial genetic data.

Related Experiment Videos

Main Results:

  • A method for detecting linkage between similar phenotypes and marker loci is presented.
  • The study successfully addresses the complexities of linkage analysis in families.
  • Identifies conditions where linkage occurs between phenotypes and multiple markers.

Conclusions:

  • The proposed solution facilitates the detection of genetic linkage in complex family structures.
  • The term "amphigenic" is introduced to describe specific linkage patterns.
  • This work contributes to the understanding of genetic basis for similar phenotypes.