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25 years of HNPCC
1Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178.
Anticancer Research
|July 1, 1994
Summary
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) research has identified key genes (MSH2, MLH1) and expanded the tumor spectrum. Management now includes genetic testing options and tailored surveillance for high-risk individuals.
Area of Science:
- Genetics and Molecular Biology
- Oncology
- Gastroenterology
Background:
- Significant advancements in understanding Hereditary Nonpolyposis Colorectal Cancer (HNPCC) over 25 years.
- Identification of autosomal dominant genetic transmission linked to MSH2 (2p) and MLH1 (3p) genes.
- Expanded tumor spectrum beyond colorectal and endometrial cancers to include urinary tract and small bowel/pancreatic adenocarcinomas.