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Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model
R Verdon1, J Polianski, C Gaudebout
1Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude-Bernard, Paris, France.
Antimicrobial Agents and Chemotherapy
|July 1, 1994
Abstract:
A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of paromomycin per kg of body weight per day.