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Interval between insulin injection and breakfast in diabetes

A H Sackey¹, I G Jefferson

¹Hull and East Yorkshire Children's Diabetes Clinic, Hull Royal Infirmary.

Archives of Disease in Childhood

|September 1, 1994

Summary

Waiting approximately 30 minutes between insulin injection and breakfast significantly improves blood glucose control in children with diabetes. Shorter intervals lead to higher blood glucose spikes after meals.

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Area of Science:

Pediatrics
Endocrinology
Metabolic Diseases

Background:

Maintaining optimal glycemic control is crucial for children with diabetes.
The timing of insulin administration relative to meals can impact postprandial glucose levels.

Purpose of the Study:

To investigate the relationship between the insulin-breakfast interval and postprandial glucose increase.
To assess the impact of this interval on overall glycemic control in diabetic children.

Main Methods:

58 children with diabetes recorded insulin-breakfast intervals over seven days.
Serial capillary blood glucose measurements were taken over 24 hours during a weekend.
Fructosamine concentrations were analyzed to assess short-term glycemic control.

Main Results:

A significant correlation was found between the insulin-breakfast interval and the postprandial rise in blood glucose.
Shorter intervals (2 minutes) resulted in a mean glucose increment of 7.2 mmol/l, while longer intervals (30 minutes) showed a 0.4 mmol/l increment.
Children with shorter intervals (2-12 minutes) had higher mean fructosamine levels (376 mumol/l) compared to those with longer intervals (15-35 minutes; 341 mumol/l).

Conclusions:

The interval between insulin injection and breakfast significantly affects morning postprandial hyperglycemia.
Encouraging a 30-minute interval between insulin administration and breakfast is recommended for improved glycemic management in children with diabetes.

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