Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Natural killer cell leukemia. An autopsy case

Y Yatabe1, N Mori, N Hirabayashi

  • 1First Department of Pathology, Nagoya University School of Medicine, Japan.

Archives of Pathology & Laboratory Medicine
|December 1, 1994
PubMed
Summary

This autopsy case details natural killer cell leukemia, a rare aggressive cancer. Findings show leukemic cells infiltrating organs, distinct from other large granular lymphocytic leukemias.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders.

Communications medicine·2026
Same author

Gastrointestinal: Relapsed Type 1 autoimmune pancreatitis mimicking pancreatic cancer.

Journal of gastroenterology and hepatology·2024
Same author

Gastrointestinal: Successful endoscopic treatment of multiple large common bile duct stones with benign biliary stricture in a case of distal gastrectomy with Billroth II reconstruction.

Journal of gastroenterology and hepatology·2022
Same author

Safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2019
Same author

Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions.

Physical review letters·2019
Same author

Early results of a randomized two-by-two factorial phase II trial comparing neoadjuvant chemotherapy with two and four courses of cisplatin/S-1 and docetaxel/cisplatin/S-1 as neoadjuvant chemotherapy for locally advanced gastric cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2017

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Natural killer (NK) cell leukemia is a rare and aggressive hematologic malignancy.
  • Distinguishing NK cell leukemia from other large granular lymphocyte (LGL) disorders is crucial for accurate diagnosis and treatment.

Observation:

  • The autopsy case presented leukemic cells with morphology of large granular lymphocytes.
  • Immunophenotypic analysis revealed a restricted NK cell phenotype (CD2+, CD38+, CD56+, HLA-DR+).
  • Immunogenotypic analysis showed germline configurations of TCR-beta, TCR-gamma, and JH genes, supporting a non-T/non-B cell lineage.

Findings:

  • The clinicopathologic features align with the definition of natural killer cell leukemia.
  • Autopsy revealed extensive leukemic cell infiltration and architectural destruction across multiple organs, correlating with an aggressive clinical course.
  • Hemophagocytic histiocytosis and lack of chronic inflammatory changes differed from CD3+ LGL leukemia.

Implications:

  • This case contributes to understanding the clinicopathologic spectrum of natural killer cell leukemia.
  • The findings highlight the importance of comprehensive immunophenotypic and immunogenotypic analysis for diagnosing rare leukemias.
  • The distinct features observed differentiate this entity from other LGL leukemias, aiding in differential diagnosis.

Related Experiment Videos