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Related Experiment Videos

Neutrophilic eccrine hidradenitis simulating orbital cellulitis

D S Bardenstein1, J Haluschak, S Gerson

  • 1Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1994
PubMed
Summary

Neutrophilic eccrine hidradenitis can cause periocular swelling and hemorrhage in chemotherapy patients. This rare condition, often mistaken for infection, requires consideration in cancer patients with similar symptoms.

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Area of Science:

  • Dermatology
  • Oncology
  • Ophthalmology

Background:

  • Orbital swelling in cancer patients often indicates neoplastic or infectious causes.
  • Diagnosis is challenging with concurrent fever and neutropenia.
  • Chemotherapy for acute myelogenous leukemia can present complex clinical scenarios.

Observation:

  • A 30-year-old male undergoing chemotherapy experienced fever and periorbital swelling.
  • Findings suggested passive swelling and hemorrhage rather than typical orbital cellulitis.
  • Skin biopsy revealed neutrophilic inflammation and eccrine gland necrosis without infection.

Findings:

  • Neutrophilic eccrine hidradenitis (NEH) was diagnosed based on skin biopsy.
  • NEH is an inflammatory condition primarily affecting eccrine glands.

Related Experiment Videos

  • This entity is most prevalent in patients undergoing induction chemotherapy.

    • Implications:

    • NEH should be included in the differential diagnosis for periocular swelling and hemorrhage in cancer patients on chemotherapy.
    • This case highlights an unusual presentation of NEH with periocular involvement.
    • Accurate diagnosis is crucial to avoid misclassification as infectious or neoplastic processes.