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Hormones and obesity

P G Kopelman1

  • 1London Hospital Medical College, UK.

Bailliere'S Clinical Endocrinology and Metabolism
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Obesity involves distinct hormonal changes, particularly in abdominal fat distribution, which may link to genetic factors and insulin resistance. Further molecular studies are needed to confirm these findings and develop a unifying theory.

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Area of Science:

  • Endocrinology
  • Genetics
  • Metabolic Disorders

Background:

  • Obesity is associated with specific hormonal alterations influenced by fat distribution.
  • Similar hormonal changes are observed in Cushing's syndrome and polycystic ovary syndrome (PCOS).
  • Animal models suggest potential hypothalamic-pituitary dysfunction in obesity.

Purpose of the Study:

  • To review evidence linking obesity, hormonal changes, and fat distribution.
  • To explore the role of abdominal adiposity in metabolic dysregulation and PCOS.
  • To investigate the genetic basis of obesity and associated hyperinsulinemia.

Main Methods:

  • Review of existing evidence on hormonal patterns in obesity.
  • Analysis of genetic heritability for body fat and abdominal fat.

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  • Preliminary investigation of candidate genes related to insulin resistance.

    • Main Results:

    • Abdominal obesity contributes to a cycle perpetuating obesity and PCOS.
    • Heritability of truncal-abdominal fat is estimated at 30-35%.
    • Upper body obesity shows distinct adipose cell characteristics and insulin response.

    Conclusions:

    • Hormonal changes in obesity are linked to fat distribution and degree.
    • Genetic factors likely contribute to hyperinsulinemia and insulin resistance in upper body obesity.
    • Further molecular studies are crucial for a unifying theory of obesity's causal factors.