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Effects of some benzodiazepines on glycemia in albino rats
1Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Romanian Journal of Physiology : Physiological Sciences
|January 1, 1993
Abstract:
The acute administration of some benzodiazepines in normoglycemic rats induced only minor changes of the blood glucose levels. In Triton WR-1339 administered rats, the benzodiazepines brought about minor modifications of this parameter. However, in diabetic rats (streptozotocin-induced diabetes), diazepam administered subacutely elicited very significant diminutions of glycemia. This was due, at least partly, to an increase of the glucose uptake by the skeletal muscle.