Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Traumatic brain injury causes a decrease in M2 muscarinic cholinergic receptor binding in the rat brain

M M DeAngelis1, R L Hayes, B G Lyeth

  • 1Department of Surgery, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0693.

Brain Research
|August 8, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

Traumatic brain injury (TBI) significantly decreased M2 muscarinic acetylcholine receptors (mAChR) in the hippocampus 24 hours post-injury. M1 mAChR binding remained unaffected, suggesting differential roles in TBI pathophysiology.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pathophysiology

Background:

  • Muscarinic acetylcholine receptors (mAChR) play a crucial role in brain function.
  • Excessive mAChR activation is implicated in the negative outcomes following traumatic brain injury (TBI).
  • Understanding the specific roles of mAChR subtypes in TBI is essential for developing targeted therapies.

Purpose of the Study:

  • To investigate the impact of moderate fluid percussion TBI on M1 and M2 mAChR binding.
  • To determine if TBI differentially affects M1 and M2 mAChR subtypes in the hippocampus and cortex.

Main Methods:

  • Quantitative autoradiography was used to assess mAChR subtype binding.
  • Specific radioligands ([3H]pirenzepine for M1, [3H]AFDX384 for M2) were employed.

Related Experiment Videos

  • Tissue samples were collected at 3 and 24 hours post-TBI.

    • Main Results:

    • TBI did not significantly alter M1 mAChR binding in the hippocampus and cortex.
    • A significant decrease in M2 mAChR binding was observed at 24 hours post-TBI in specific hippocampal regions (CA2-3, dentate gyrus).

    Conclusions:

    • M2 mAChR subtypes are vulnerable to TBI, showing reduced binding in key hippocampal areas.
    • M1 and M2 mAChR subtypes appear to be differentially affected by TBI, suggesting distinct pathophysiological contributions.