Colonic bull's-eye lesions in histiocytosis X

A 27-year-old woman with known pulmonary, cutaneous and osseous histiocytosis X presented with vague abdominal pain. Double-contrast barium enema examination revealed multiple colonic bull's-eye lesions. Biopsy showed histiocytic infiltration similar to that already described at other sites in this patient (the lungs and bone). To the authors' knowledge, this case represents the first radiologic description of this manifestation of histiocytosis X. Though rare, it should be considered in the differential diagnosis of colonic bull's-eye lesions.