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Nodular transformation of splenic red pulp due to carcinomatous infiltration. A diagnostic pitfall
1Sikl's Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic.
Histopathology
|August 1, 1994
Abstract:
Autopsy of three women dying of disseminated carcinoma of stomach, colon, and breast, respectively, revealed a grossly unremarkable spleen. Microscopic examination demonstrated a nodular transformation of the red pulp, simulating a follicular lymphoma. Immunostaining revealed dissociated carcinomatous cells between the nodules, and this was thought to be the cause of the nodular transformation.